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- Title
The lack of effect of isoflavones on high-density lipoprotein cholesterol concentrations in adolescent boys: a 6-week randomised trial.
- Authors
Dwyer T; Hynes KL; Fryer JL; Blizzard CL; Dalais FS; Dwyer, Terence; Hynes, Kristen L; Fryer, Jayne L; Blizzard, C Leigh; Dalais, Fabien S
- Abstract
<bold>Background: </bold>A substantial fall in high-density lipoprotein cholesterol (HDL-C) during puberty in boys, but not girls, has been reported in Western populations. The fall in boys is believed to be due to hormonal changes--androgens have been shown to be associated with lower HDL-C, whereas oestrogens are associated with higher HDL-C. The fall in HDL-C during puberty was not observed, however, in a study of Moslem boys in Israel, nor in a group of Japanese boys. A diet high in phyto-oestrogens may account for the lack of a fall in HDL-C in these populations.<bold>Objective: </bold>To examine the effect of dietary supplementation with phyto-oestrogens on the HDL-C concentration of adolescent boys from a Western population. We hypothesised that dietary supplementation of 50 mg of the isoflavones daidzein and genistein would produce a 12% higher HDL-C concentration than in controls at the end of a 6-week intervention period.<bold>Design: </bold>A randomised controlled trial.<bold>Setting: </bold>Hellyer College in Burnie (Tasmania, Australia).<bold>Subjects: </bold>Adolescent boys (aged 16-18 years) were recruited through a letter sent to parents. A total of 132 eligible participants enrolled and five subjects withdrew from the trial.<bold>Results: </bold>No significant increase in HDL-C was observed in the treatment group (-0.02 mmol l(-1), standard error (SE)=0.03, P = 0.53) or the placebo group (0.05 mmol l(-1), SE = 0.03, P = 0.11).<bold>Conclusions: </bold>Factors other than isolated dietary isoflavones may be responsible for the lack of fall in HDL-C during puberty in Japanese and Moslem boys.
- Publication
Public Health Nutrition, 2008, Vol 11, Issue 9, p955
- ISSN
1368-9800
- Publication type
journal article
- DOI
10.1017/s1368980007000869