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- Title
Optimization of [<sup>11</sup>C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification.
- Authors
Torrent, Èlia; Farré, Magí; Abasolo, Ibane; Millan, Olga; LLop, Jordi; Gispert, Juan Domingo; Ruiz, Alba; Pareto, Deborah
- Abstract
The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [11C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [11C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences.
- Subjects
MATHEMATICAL optimization; CARBON isotopes; POSITRON emission tomography; LABORATORY rats; COMPARATIVE studies; MEDICAL imaging systems; IMAGE reconstruction; ALGORITHMS
- Publication
Molecular Imaging, 2013, Vol 12, Issue 4, p257
- ISSN
1535-3508
- Publication type
Article
- DOI
10.2310/7290.2012.00040