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- Title
Fibrosis-4 Index as a Predictor for Disease Severity and Mortality in Patients with COVID-19.
- Authors
NALBANT, Ahmet; KAYA, Tezcan; YAYLACI, Selçuk; AYDIN, Ayhan; İŞSEVER, Kubilay; GENÇ, Ahmet Cihad
- Abstract
Objective: The Fibrosis-4 (FIB-4) index is a noninvasive marker of liver fibrosis in various patient populations. We examined whether there is a relationship between the severity and prognosis of COVID-19 disease and the FIB-4 index. Materials and Methods: This study is cross-sectional and retrospective. The patients were divided into two groups: those hospitalized in the intensive care unit (ICU) and those hospitalized in the clinic (non-ICU). Results: Of the 158 cases, 86(54%) were male. Age, total bilirubin, AST levels and FIB-4 index were higher in ICU patients compared to non-ICUs (p<0.001,p=0.002, p=0.003, p<0.001 respectively). FIB-4 index nonsurvivors were also higher (p=0.002). When the effect of the FIB-4 index on the severity of COVID-19 disease and mortality was evaluated by ROC analysis, both ICU and non-survivors were found to be significant (respectively, FIB-4 score; AUC=0.705,95%CI:0.624-785,p<0.001; AUC=0.654,95%CI:0.566-742,p=0.002). When the FIB-4 index cut-off value for disease severity was taken as 2.19, 70.0% sensitivity and 60% specificity were found in predicting disease severity. Moreover, when the FIB-4 index cut-off value for mortality was taken as 2.19, 71.2% sensitivity and 53% specificity were found in predicting mortality. Conclusions: The FIB-4 index is an independent predictor of severity and mortality in COVID-19 patients requiring ICU.
- Subjects
FIBROSIS; MORTALITY; COVID-19 pandemic; BILIRUBIN; HOSPITAL patients
- Publication
Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi, 2023, Vol 8, Issue 1, p134
- ISSN
2459-1467
- Publication type
Article
- DOI
10.26453/otjhs.1153625