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- Title
Evaluation of the Relationship between Pain Exposure and Somatosensory Evoked Potentials in Preterm Infants: A Prospective Cohort Study.
- Authors
Coviello, Caterina; Lori, Silvia; Bertini, Giovanna; Montano, Simona; Gabbanini, Simonetta; Bastianelli, Maria; Cossu, Cesarina; Cavaliere, Sara; Lunardi, Clara; Dani, Carlo
- Abstract
Background and aim: First, to compare somatosensory evoked potentials (SEPs) in preterm newborns without major brain injury studied at term equivalent age (TEA) with a term historical control group. Second, to investigate the impact of pain exposure during the first 28 days after birth on SEPs. Third, to evaluate the association between SEPs and Bayley-III at 2 years corrected age (CA). Methods: Infants born at <32 weeks' gestational age (GA) were studied with continuous-SEPs. First, SEP differences between preterm and term infants were analyzed. Second, regression analyses were conducted to explore the association between SEPs and painful procedures, and then between SEPs and neurodevelopment. Results: 86 preterm infants were prospectively enrolled. Preterm infants exhibited prolonged N1 latencies, central conduction times (CCTs), lower N1-P1 amplitudes, and more recurrently abnormal SEPs compared to term infants. Higher pain exposure predicted longer N1 latency and slower CCT (all p < 0.005), adjusting for clinical risk factors. Younger GA and postmenstrual age (PMA) at SEP recording were associated with longer N1 latency and lower N1-P1 amplitude (all p < 0.005). A normal SEP at TEA positively predicted cognitive outcome at 2 years CA (p < 0.005). Conclusion: Pain exposure and prematurity were risk factors for altered SEP parameters at TEA. SEPs predicted cognitive outcome.
- Subjects
ITALY; RISK assessment; SOMATOSENSORY evoked potentials; T-test (Statistics); NEURAL development; NEONATAL intensive care units; DESCRIPTIVE statistics; CHI-squared test; MULTIVARIATE analysis; NEONATAL intensive care; SURGICAL complications; LONGITUDINAL method; DURATION of pregnancy; PAIN; PAIN management; ARTIFICIAL respiration; BRAIN injuries; DATA analysis software; CONFIDENCE intervals; REGRESSION analysis; AUDITORY evoked response; COGNITION; DISEASE risk factors
- Publication
Children, 2024, Vol 11, Issue 6, p676
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children11060676