We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Role of Erythropoietin in Preventing Anemia in the Premature Neonate.
- Authors
Costescu, Oana Cristina; Boia, Eugen Radu; Boia, Marioara; Cioboata, Daniela Mariana; Doandes, Florina Marinela; Lungu, Nicoleta; Dinu, Mihai; Iacob, Emil Radu; Manea, Aniko Maria
- Abstract
Recombinant human erythropoietin (rhEPO) treatment is an alternative to red blood cell (RBC) transfusions in neonates presenting anemia of prematurity (AOP). This study assesses the impact of early rhEPO administration on AOP (any stage) incidence, as well as the incidence of individual AOP stages and RBC transfusions. Out of 108 preterm neonates, 49 were administered rhEPO and compared to the remaining group using univariate and multivariate analyses. Univariately, gestational age (GA), birth weight (BW), hemoglobin (Hb), hematocrit (HCT), RBC levels, and iron administration were significantly associated with AOP (p < 0.05 each); however, only the latter remained significant following multivariate analysis (AOR: 2.75, 95% CI, 1.06–7.11). Multinomial analysis revealed rhEPO treatment was associated with a near three-fold reduction in moderate AOP incidence (OR: 0.36, 95% CI, 0.15–0.89). Furthermore, ANCOVA revealed positive correlations between rhEPO administration and 21-day Hb (p < 0.01), HCT (p < 0.05), and EPO (p < 0.001) levels. The results confirm previously reported benefits of rhEPO treatment, such as reduced moderate AOP incidence and increased Hb, HCT, and serum EPO levels.
- Subjects
EXPERIMENTAL design; PROTHROMBIN time; PARTIAL thromboplastin time; NEONATAL anemia; HEMOGLOBINS; HEMATOCRIT; MULTIPLE regression analysis; GESTATIONAL age; DISEASE incidence; TREATMENT effectiveness; COMPARATIVE studies; BIRTH weight; DESCRIPTIVE statistics; CHI-squared test; RED blood cell transfusion; ODDS ratio; ERYTHROPOIETIN; RECOMBINANT proteins
- Publication
Children, 2023, Vol 10, Issue 12, p1843
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10121843