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- Title
Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells.
- Authors
Anderson, Howard A.; Maylock, Caroline A.; Williams, Joy A.; Paweletz, Cloud P.; Shu, Hongjun; Shacter, Emily
- Abstract
Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here we identified protein S as the factor responsible for serum-stimulated phagocytosis of apoptotic cells. Protein S is best known for its anti-thrombotic activity, serving as a cofactor for protein C. Purified protein S was equivalent to serum in its ability to stimulate macrophage phagocytosis of apoptotic lymphoma cells, and immunodepletion of protein S eliminated the prophagocytic activity of serum. Protein S acted by binding to phosphatidylserine expressed on the apoptotic cell surface. Protein S is thus a multifunctional protein that can facilitate clearance of early apoptotic cells in addition to regulating blood coagulation.
- Subjects
PROTEIN S; PHAGOCYTOSIS; APOPTOSIS
- Publication
Nature Immunology, 2003, Vol 4, Issue 1, p87
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni871