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- Title
Final steps of natural killer cell maturation: a model for type 1?type 2 differentiation?
- Authors
Loza, Matthew J.; Perussia, Bice
- Abstract
Analysis of cytokine and differentiation antigen expression in human natural killer (NK) cells revealed that interleukin 13 (IL-13) and interferon γ (IFN-γ) are produced at sequential stages during irreversible IL-12?induced differentiation. In human NK cell clones, polyclonal CD3-CD161+CD56- cells and peripheral lymphocytes, IL-4 induced the proliferation of both IL-13+ NK and T cells, whereas IL-12 allowed a proliferation-independent accumulation of IFN-γ+ cells. These data disproved the NK1-NK2 hypothesis and challenge the current T helper 1 (TH1)-TH2 paradigm. We propose that the cytokine environment regulates a type 2→0→1 developmental progression, with IL-12 needed for terminal differentiation and IL-4 delaying this process, rather than a type 1 versus type 2 decision of a type 0 cell.
- Subjects
KILLER cells; CELL differentiation; INTERFERONS; CHEMICAL inhibitors
- Publication
Nature Immunology, 2001, Vol 2, Issue 10, p917
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1001-917