We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Association of Metabolic Syndrome with Executive Dysfunction Independent of Subclinical Ischemic Brain Lesions in Japanese Adults.
- Authors
Bokura, Hirokazu; Nagai, Atsushi; Oguro, Hiroaki; Kobayashi, Shotai; Yamaguchi, Shuhei
- Abstract
Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44-86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17-1.25 for Kohs' Test; OR = 2.25, 95% CI = 1.64-3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function. Conclusion: Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population. Copyright © 2011 S. Karger AG, Basel
- Subjects
BRAIN; CHI-squared test; COMPUTER software; GLUCOSE; ISCHEMIA; JAPANESE people; MAGNETIC resonance imaging; NONPARAMETRIC statistics; RESEARCH funding; T-test (Statistics); U-statistics; WECHSLER Adult Intelligence Scale; LOGISTIC regression analysis; DATA analysis; METABOLIC syndrome; DISEASE complications
- Publication
Dementia & Geriatric Cognitive Disorders, 2011, Vol 30, Issue 6, p479
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000322057