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- Title
Prediction of the Rate of Decline in Cognitive Function in Alzheimers Disease: A Model Based on Simple Demographic Data and Widely Used Rating Scales.
- Authors
S. Johnsen; S. Hughes; R. Bullock; I. Hindmarch
- Abstract
Dementia represents a significant burden on the resources of both the National Health Service and Social Services as well as a great strain on the caregivers. The ability to predict, at diagnosis, those dementia patients that will deteriorate rapidly would allow a more effective allocation of resources as well as enabling the families and caregivers to make appropriate preparations. We performed discriminant analysis on a placebo data set of over 5,000 patients with Alzheimers disease in order to create a model that predicts the rate of cognitive decline in Alzheimers disease from simple demographic data and the baseline score on the cognitive subscale of the Alzheimers Disease Assessment Scale or the Mini Mental State Examination. This model has 9697% sensitivity and 9293% specificity. The potential benefits of this model argue for its validation in a prospective study.Copyright © 2003 S. Karger AG, Basel
- Subjects
ALZHEIMER'S disease; PRESENILE dementia; COGNITION; NEUROBEHAVIORAL disorders; BRAIN diseases
- Publication
Dementia & Geriatric Cognitive Disorders, 2003, Vol 16, Issue 4, p276
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000072813