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- Title
Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation.
- Authors
Niwa, Akira; Umeda, Katsutsugu; Awaya, Tomonari; Yui, Yoshihiro; Matsubara, Hiroshi; Hiramatsu, Hidefumi; Watanabe, Ken-Ichiro; Adachi, Souichi; Itoh, Takashi; Uemoto, Shinji; Nakahata, Tatsutoshi
- Abstract
A four-yr-old boy developed a solitary metastasis nine months after living-related liver transplantation for unresectable hepatoblastoma. After resection of the metastatic lesion, he received an auto-PBSCT with a double-conditioning regimen consisting of melphalan and thiotepa. Auto-PBSCT could be safely performed without any serious regimen-related toxicity or infection. However, transient cessation of tacrolimus during myelosuppression resulted in graft rejection of the liver just after hematological engraftment, but rejection was resolved by tacrolimus and methylprednisolone. The patient is alive and free from disease two yr after auto-PBSCT without any signs of graft rejection. High-dose chemotherapy using this conditioning regimen may be feasible for recurrent hepatoblastoma after liver transplantation in terms of safety and anti-tumor activity.
- Subjects
STEM cell transplantation; LIVER transplantation; JUVENILE diseases; GRAFT rejection; COMPLICATIONS from organ transplantation
- Publication
Pediatric Transplantation, 2009, Vol 13, Issue 2, p259
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/j.1399-3046.2008.00948.x