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- Title
Continued smoking and posterior vitreous adhesion in the elderly evaluated on swept-source optical coherence tomography.
- Authors
Toyama, Taku; Hashimoto, Yohei; Kawai, Hisashi; Azuma, Kunihiro; Shiraya, Tomoyasu; Araki, Fumiyuki; Sugimoto, Koichiro; Watanabe, Yutaka; Hirano, Hirohiko; Fujiwara, Yoshinori; Ihara, Kazushige; Kim, Hunkyung; Kato, Satoshi; Numaga, Jiro; Obuchi, Shuichi; Ueta, Takashi
- Abstract
In this cross-sectional study including 1150 eyes of 681 volunteers ≧ 65 years old without retinal pathology, factors affecting the progression of posterior vitreous detachment (PVD) were investigated. PVD stages were diagnosed based on swept-source optical coherence tomography (SS-OCT). Linear mixed effect model was used to determine whether age, gender, diabetes mellitus (DM), hypertension (HT), dyslipidemia (DL), and smoking status were associated with various stages of PVD. As a result, the multivariable analysis disclosed that the associations between older age and higher PVD stages (estimate [95% CI], 0.031 [0.020 to 0.042]; P < 0.0001), and current smokers and lower PVD stages (estimate [95% CI], − 0.24 [− 0.43 to − 0.056]; P = 0.011) were statistically significant. In contrast, female gender was not an independent factor affecting PVD stages in the elderly. Our analysis indicated that higher PVD stages observed in female eyes may be due to confounding effect, in which current smokers were predominantly males (i.e., 12.6% among males vs. 3.9% among females, P < 0.0001). In conclusion, our findings suggest that continuous smoking is associated with an adherent vitreoretinal interface in the elderly.
- Subjects
VITREOUS body diseases; RETINAL disease diagnosis; RETINAL detachment; OPTICAL coherence tomography; PHYSIOLOGICAL effects of tobacco; DISEASES in older people
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-75590-9