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Digital Research Environment(DRE)-enabled Artificial Intelligence (AI) to facilitate early stage drug development.
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- Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1115356
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- Article
Landscape analysis for a neonatal disease progression model of bronchopulmonary dysplasia: Leveraging clinical trial experience and real-world data.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.988974
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- Article
Editorial: Insights in obstetric and pediatric pharmacology: 2021.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.995923
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- Article
History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications.
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- Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.637999
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- Article
Consideration of the Root Causes in Candidate Attrition During Oncology Drug Development.
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- Clinical Pharmacology in Drug Development, 2024, v. 13, n. 9, p. 952, doi. 10.1002/cpdd.1464
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- Article
Role of Disease Progression Models in Drug Development.
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- Pharmaceutical Research, 2022, v. 39, n. 8, p. 1803, doi. 10.1007/s11095-022-03257-3
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- Publication type:
- Article
Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach.
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- Pharmaceutical Research, 2018, v. 35, n. 9, p. 1, doi. 10.1007/s11095-018-2458-6
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- Article
Clinical and Pharmacokinetic Characteristics of Intracavitary Administration of Pegylated Liposomal Encapsulated Doxorubicin in Dogs with Splenic Hemangiosarcoma.
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- Journal of Veterinary Internal Medicine, 2007, v. 21, n. 6, p. 1347, doi. 10.1111/j.1939-1676.2007.tb01958.x
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- Article
Diagnosing malabsorption with systemic lipid profiling: pharmacokinetics of pentadecanoic acid and triheptadecanoic acid following oral administration in healthy subjects and subjects with cystic fibrosis.
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- International Journal of Clinical Pharmacology & Therapeutics, 2013, v. 51, n. 4, p. 263, doi. 10.5414/CP201793
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- Article
Disposition and exposure of the fibrinogen receptor antagonist XV459 on α<sub>IIB</sub>β<sub>3</sub> binding sites in the guinea pig.
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- Biopharmaceutics & Drug Disposition, 1999, v. 20, n. 6, p. 309, doi. 10.1002/(SICI)1099-081X(199909)20:6<309::AID-BDD190>3.0.CO;2-7
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- Publication type:
- Article
Pharmacokinetic evaluation of a selegiline pulsatile oral delivery system.
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- Biopharmaceutics & Drug Disposition, 1997, v. 18, n. 8, p. 665, doi. 10.1002/(SICI)1099-081X(199711)18:8<665::AID-BDD47>3.0.CO;2-A
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- Publication type:
- Article
Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration.
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- Biopharmaceutics & Drug Disposition, 1997, v. 18, n. 7, p. 567, doi. 10.1002/(SICI)1099-081X(199710)18:7<567::AID-BDD49>3.0.CO;2-7
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- Publication type:
- Article
TOXICOKINETIC EVALUATION OF A SELEGILINE TRANSDERMAL SYSTEM IN THE DOG.
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- Biopharmaceutics & Drug Disposition, 1997, v. 18, n. 2, p. 165, doi. 10.1002/(SICI)1099-081X(199703)18:2<165::AID-BDD14>3.0.CO;2-S
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- Publication type:
- Article
An AI Approach to Generating MIDD Assets Across the Drug Development Continuum.
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- AAPS Journal, 2023, v. 25, n. 4, p. 1, doi. 10.1208/s12248-023-00838-x
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- Publication type:
- Article
A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.
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- AAPS Journal, 2019, v. 21, n. 5, p. N.PAG, doi. 10.1208/s12248-019-0351-9
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- Publication type:
- Article
Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants.
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- AAPS Journal, 2013, v. 15, n. 2, p. 447, doi. 10.1208/s12248-013-9452-z
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- Publication type:
- Article
A Sensitive and Selective Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Analysis of Efavirenz in Human Plasma.
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- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0063305
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- Article
A Randomized, Placebo Controlled, Double Masked Phase IB Study Evaluating the Safety and Antiviral Activity of Aprepitant, a Neurokinin-1 Receptor Antagonist in HIV-1 Infected Adults.
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- PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024180
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- Article
A sensitive and selective liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of actinomycin-D and vincristine in children with cancer.
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- Journal of Mass Spectrometry, 2007, v. 42, n. 6, p. 761, doi. 10.1002/jms.1211
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- Publication type:
- Article
Pharmacokinetics and pharmacodynamics of MK-383, a selective non-peptide platelet glycoprotein-IIb/IIIa receptor antagonist, in healthy men.
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- Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 4, p. 377, doi. 10.1038/clpt.1994.152
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- Article
Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy.
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- BMC Medical Informatics & Decision Making, 2008, v. 8, n. 1, p. 1, doi. 10.1186/1472-6947-8-6
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- Article
Asking More of Our EHR Systems to Improve Outcomes for Pediatric Patients.
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- Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00253
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- Article
Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.
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- British Journal of Clinical Pharmacology, 2015, v. 80, n. 5, p. 1185, doi. 10.1111/bcp.12693
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- Article
Paediatric models in motion: requirements for model-based decision support at the bedside.
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- British Journal of Clinical Pharmacology, 2015, v. 79, n. 1, p. 85, doi. 10.1111/bcp.12287
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- Publication type:
- Article
Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators.
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- Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017711414
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- Article
A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics.
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- Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017710941
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- Article
Identifying novel phenotypes of vulnerability and resistance to activity-based anorexia in adolescent female rats.
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- International Journal of Eating Disorders, 2013, v. 46, n. 7, p. 737, doi. 10.1002/eat.22149
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- Article
Artificial Intelligence Opportunities to Guide Precision Dosing Strategies.
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- Journal of Pediatric Pharmacology & Therapeutics, 2024, v. 29, n. 4, p. 434, doi. 10.5863/1551-6776-29.4.434
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- Article
The Precompetitive Space for Drug or Vaccine Development: What Does It Look Like Now and What Could It Look Like in the Future?
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- Journal of Pediatric Pharmacology & Therapeutics, 2023, v. 28, n. 5, p. 465, doi. 10.5863/1551-6776-28.5.465
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- Article
A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children.
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00151
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- Article
Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00136
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- Article
Systems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities.
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- Frontiers in Pharmacology, 2015, v. 6, p. 1, doi. 10.3389/fphar.2015.00033
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- Article
A Modern Curriculum for Training Scientists in Model‐Informed Drug Development: Progress Report on FDA Grant to Train Regulatory Scientists.
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- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 2, p. 289, doi. 10.1002/cpt.3039
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- Article
Time to Expect More From Pharmacometrics.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 6, p. 1129, doi. 10.1002/cpt.1914
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- Article
Pediatric Extrapolation in Type 2 Diabetes: Future Implications of a Workshop.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 1, p. 29, doi. 10.1002/cpt.1805
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- Article
Real‐World Data: An Unrealized Opportunity in Global Health?
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- Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 1, p. 57, doi. 10.1002/cpt.1476
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- Article
Challenges and Opportunities With Oncology Drug Development in China.
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- Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 2, p. 363, doi. 10.1002/cpt.1017
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- Article
Leveraging Big Data in Pediatric Development Programs: Proceedings From the 2016 American College of Clinical Pharmacology Annual Meeting Symposium.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 1, p. 81, doi. 10.1002/cpt.975
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- Article
Challenges and Opportunities in the Development of Medical Therapies for Pediatric Populations and the Role of Extrapolation.
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- Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 3, p. 419, doi. 10.1002/cpt.1000
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- Article
Prescribing habits and caregiver satisfaction with resources for dosing children: Rationale for more informative dosing guidance.
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- BMC Pediatrics, 2011, v. 11, n. 1, p. 25, doi. 10.1186/1471-2431-11-25
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- Article
Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults.
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- Cancer Chemotherapy & Pharmacology, 2009, v. 63, n. 2, p. 229, doi. 10.1007/s00280-008-0730-x
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- Publication type:
- Article
A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of actinomycin-D and vincristine in children with cancer.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 4, p. 458, doi. 10.1007/s00280-005-0065-9
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- Publication type:
- Article
Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 797, doi. 10.1002/psp4.12801
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- Publication type:
- Article
A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 7, p. 374, doi. 10.1002/psp4.12506
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- Article
Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 10, p. 629, doi. 10.1002/psp4.12338
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- Article
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 7, p. 442, doi. 10.1002/psp4.12304
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- Article
Drug Dosing and Pharmacokinetics in Children With Obesity.
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- JAMA Pediatrics, 2015, v. 169, n. 7, p. 678, doi. 10.1001/jamapediatrics.2015.132
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- Article
Application and impact of population pharmacokinetics in the assessment of antiretroviral pharmacotherapy.
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- 2005
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- Publication type:
- journal article
Pharmacodynamic Analysis of the Microbiological Efficacy of Telithromycin in Patients with Community-Acquired Pneumonia.
- Published in:
- Clinical Pharmacokinetics, 2005, v. 44, n. 3, p. 317, doi. 10.2165/00003088-200544030-00007
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- Article
Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.
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- Journal of Clinical Pharmacology, 2016, v. 56, n. 11, p. 1326, doi. 10.1002/jcph.744
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- Article