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- Title
A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.
- Authors
Ho, Tammy Szu-Yu; Zollinger, Daniel R; Chang, Kae-Jiun; Xu, Mingxuan; Cooper, Edward C; Stankewich, Michael C; Bennett, Vann; Rasband, Matthew N
- Abstract
The scaffolding protein ankyrin-G is required for Na+ channel clustering at axon initial segments. It is also considered essential for Na+ channel clustering at nodes of Ranvier to facilitate fast and efficient action potential propagation. However, notwithstanding these widely accepted roles, we show here that ankyrin-G is dispensable for nodal Na+ channel clustering in vivo. Unexpectedly, in the absence of ankyrin-G, erythrocyte ankyrin (ankyrin-R) and its binding partner βI spectrin substitute for and rescue nodal Na+ channel clustering. In addition, channel clustering is also rescued after loss of nodal βIV spectrin by βI spectrin and ankyrin-R. In mice lacking both ankyrin-G and ankyrin-R, Na+ channels fail to cluster at nodes. Thus, ankyrin R-βI spectrin protein complexes function as secondary reserve Na+ channel clustering machinery, and two independent ankyrin-spectrin protein complexes exist in myelinated axons to cluster Na+ channels at nodes of Ranvier.
- Subjects
ANKYRINS; ADAPTOR proteins; SPECTRIN; NODES of Ranvier; NEUROSCIENCES
- Publication
Nature Neuroscience, 2014, Vol 17, Issue 12, p1664
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3859