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- Title
Molecular and Cellular Characterization of Human CD8 T Suppressor Cells.
- Authors
Zheng Xu; Sophey Ho; Chih-Chao Chang; Qing-Yin Zhang; Vasilescu, Elena-Rodica; Vlad, George; Suciu-Foca, Nicole
- Abstract
Bidirectional interactions between dendritic cells and Ag-experienced T cells initiate either a tolerogenic or immunogenic pathway. The outcome of these interactions is of crucial importance in malignancy, transplantation, and autoimmune diseases. Blockade of costimulation results in the induction of T helper cell anergy and subsequent differentiation of antigen-specific CD8+ T suppressor/regulatory cells (Ts). Ts, primed in the presence of inhibitory signals, exert their inhibitory function in an antigen-specific manner, a feature with tremendous clinical potential. In transplantation or autoimmunity, antigen-specific Ts can enforce tolerance to auto- or allo-antigens, while otherwise leaving the immune response to pathogens uninhibited. Alternatively, blockade of inhibitory receptors results in the generation of cytolytic CD8+ T cells, which is vital toward defense against tumors and viral diseases. Because CD8+ T cells are MHC Class I restricted, they are able to recognize HLA-bound antigenic peptides presented not only by APC but also on parenchymal cells, thus eliciting or suppressing auto- or allo-immune reactions.
- Subjects
CD8 antigen; SUPPRESSOR cells; GENETICS of autoimmune diseases
- Publication
Frontiers in Immunology, 2016, Vol 7, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00549