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- Title
Relationship of angiographic finding with neovascular structure detected by immunohistochemical staining of α-smooth muscle actin in small hepatocellular carcinoma.
- Authors
IKEDA, KENJI; SAITOH, SATOSHI; SUZUKI, YOSHIYUKI; KOBAYASHI, MASAHIRO; TSUBOTA, AKIHITO; KOIDA, ISAO; KOBAYASHI, MIZUHO; ARASE, YASUJI; CHAYAMA, KAZUAKI; MURASHIMA, NAOYA; KUMADA, HIROMITSU; Ikeda, Kenji
- Abstract
To elucidate the relationship between angiographic features and histological findings, an immunohistological study of α-smooth muscle actin was performed in 106 patients with small hepatocellular carcinoma. Arterial dominance or portal blood paucity were found in 73 patients (68.9%) on digital subtraction angiography, 88 (83.0%) on computerized tomographic arterial portography and 87 (82.1%) on carbon dioxide-enhanced ultrasonography. Among 73 patients with hypervascularity on angiography, 57 (78.1%) had thick-walled, nuclei-rich and slender-shaped vessels (type II), eight (11.0%) had thin-walled, nuclei-poor and oval-shaped vessels (type I) and the remaining eight had a mixed type of II and I. Conversely, among 33 patients without hypervascularity, five (15.2%) had a type II, 21 (63.6%) had a type I, five had a mixed type and two had no positive vessel. Tumour size, histological classification and amount of non-triadal vessels were also associated with the angiographic appearance of the tumours. Among varied aspects of the cancer including tumour size, tumour multiplicity, microscopic portal invasion, histological classification, amount of α-smooth muscle actin-positive vessels and shape of α-smooth muscle actin-positive vessels, multivariate logistic regression analysis demonstrated that the shape of α-smooth muscle actin-positive vessels was solely associated with angiographic hypervascularity independently (P < 0.0001). Although the existence of non-triadal vessels characterized hepatocellular carcinoma, angiographic hypervascularity was closely associated with the type II vessel. A morphological change of non-triadal vessel from type I to type II was considered to occur in an early stage of hepatocellular carcinoma.
- Subjects
ACTIN; LIVER cancer patients; ANGIOGRAPHY; LIVER radiography; IMMUNOHISTOCHEMISTRY
- Publication
Journal of Gastroenterology & Hepatology, 1998, Vol 13, Issue 12, p1266
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.1998.tb00616.x