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- Title
A unified pharmacokinetic approach to individualized drug dosing.
- Authors
Begg, Evan J.; Chin, Paul K. L.
- Abstract
The author discusses the determinants and a unified approach of measuring the right dose for drugs for adult patients. It is mentioned that for maintenance dosing the most important determinant is clearance (CL) and the half-life is important for choice of dose interval. It is also mentioned that dose-rate adjustment is most clear for drugs with predominantly renal elimination.
- Subjects
PHARMACEUTICAL arithmetic; DRUG dosage; PHARMACOKINETICS; METABOLISM; PHARMACOGENOMICS; ENZYMES
- Publication
British Journal of Clinical Pharmacology, 2012, Vol 73, Issue 3, p335
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/j.1365-2125.2011.04089.x