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- Title
Clinical Study of Cyclocytidine in Children With Acute Leukemia.
- Authors
ISE, TOHRU; OHTSUKI, HIROSHI; AKATSUKA, JUNICHI; TSUKIMOTO, ICHIRO; HANAWA, YOSHIYUK.I; NAGAO, TAKESHI; ISHIKAWA, AKIRA; KOIDE, RYO; TAGUCHI, NOBUYUKl; KUDO, HTSAO; MATSUYAMA, SHUSUKE; NISHIMURA, KOZO; OHMI, KEIKO; SHIKE, SEIJCHIRO; UEDA, YUTAKA; YOSHLKAWA, TOSHIO
- Abstract
One hundred children with various types of leukemia were given 113 treatments with cyclocytidine. Eighty-four of these patients had been treated previously. Cyclocytidine was daily given intravenously for four to 11 consecutive days in amounts of 20mg/kg or 500mg/m2. The treatment course . was repeated, when necessary.Complete remission was obtained in one case of monocytic leukemia among six treated by cyclocytidine alone. Combined therapy with steroid hormone gave 14 complete and eight partial remissions in 38 cases, the remission rate standing at 58%. There were 30 complete and 16 partial remissions in 69 cases treated with combination therapy with two or more agents, and the remission rate was 67%.Transient pains in the region of the parotid gland were the most characteristic toxicity. GI tract symptoms were less common and milder than those of cytosine arabinoside. Dizziness was noticed in three cases.Nine children with acute leukemia who were given cyclocytidine orally showed no remarkable response.Cyclocytidine, given parenterally, seems beneficial for various types of leukemia in children.
- Publication
Japanese Journal of Clinical Oncology, 1976, Vol 6, Issue 1, p1
- ISSN
0368-2811
- Publication type
Article