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- Title
Investigation of the Effects of Boric Acid on Preventing Lung Damage in the End of the Lower Extremity Ischemia Reperfusion in Rats.
- Authors
Özcan, Cahit; Bengü, Aydın Şükrü; Akkoyun, H. Turan; Ulucan, Aykut; Akkoyun, Mahire Bayramoglu
- Abstract
In this study, the biochemical and histopathological changes in the lungs due to lower extremity ischemiareperfusion injury and protective effect of boric acid to prevent them were investigated. The rats were divided into three groups as Group 1 (Sham group, n=9), Group 2 (Ischemia-reperfusion group, I/R, n=9) and Group 3 (Ischemiareperfusion, (I/R) + boric acid (BA), n=9). Anaesthesia was applied to the first group of rats without any ischemiareperfusion process. Following a two-hour ischemia, two hours of reperfusion, with the help of left lower extremities tourniquet, were applied to the second group. To the third group, 200 mg/kg (i.p.) boric acid application was performed 10 minutes before the ischemia was initiated and two hours of ischemia and two hours of reperfusion application were carried out. Some antioxidant enzymes in lung tissue (SOD, GSH-Px, CAT) were analyzed. In addition the lung tissue was evaluated histopathologically. Boric acid application was found to significantly enhance the positive effect of antioxidant enzymes. Normal histological structure was better preserved, some of macrophages were non-activated, and a remarkable reduction of neutrophil infiltration was seen after treatment in boric acid given group.
- Subjects
BORIC acid; REPERFUSION; ISCHEMIA; LUNGS; RATS; LEG
- Publication
Journal of Faculty of Veterinary Medicine, Erciyes University / Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 2020, Vol 17, Issue 1, p57
- ISSN
1304-7280
- Publication type
Article
- DOI
10.32707/ercivet.705004