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- Title
Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial.
- Authors
Alharbi, Mushari; Chiurazzi, Martina; Nasti, Gilda; Muscariello, Espedita; Mastantuono, Teresa; Koechl, Christina; Stephan, Blossom CM; Shannon, Oliver M; Colantuoni, Antonio; Siervo, Mario
- Abstract
Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. This was a two-arm, parallel randomized clinical trial including 29 participants allocated to CR + BRJ (n = 15) or CR alone (n = 14) for 14 days. Body composition, resting energy expenditure (REE), and hand-grip strength were measured. Resting blood pressure (BP) and microvascular endothelial function were measured, and Trail-Making Test A and B were used to assess cognitive function. Salivary nitrate and nitrite, and urinary nitrate and 8-isoprostane concentrations were measured. Changes in body composition, REE, and systolic and diastolic BP were similar between the two interventions (p > 0.05). The CR + BRJ intervention produced greater changes in average microvascular flux (p = 0.03), NO-dependent endothelial activity (p = 0.02), and TMT-B cognitive scores (p = 0.012) compared to CR alone. Changes in urinary 8-isoprostane were greater in the CR + BRJ group (p = 0.02), and they were inversely associated with changes in average microvascular flux (r = −0.53, p = 0.003). These preliminary findings suggest that greater effects on vascular and cognitive functions could be achieved by combining CR with dietary nitrate supplementation.
- Subjects
ENDOTHELIUM physiology; SALIVA analysis; ENERGY metabolism; OBESITY; PILOT projects; BODY composition; FOOD consumption; BEETS; NITRATES; DIETARY supplements; PHYSIOLOGICAL adaptation; RANDOMIZED controlled trials; DESCRIPTIVE statistics; RESEARCH funding; VASCULAR diseases; COGNITIVE testing; STATISTICAL sampling; NITRIC oxide
- Publication
Nutrients, 2023, Vol 15, Issue 4, p890
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15040890