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- Title
Cytokines and C-reactive protein in moderate and severe preeclampsia.
- Authors
Markova, Ana Daneva; Lega, Marija Hadzi; Popovic, Jasmina
- Abstract
Objective: Studying the production of pro-inflammatory (IL-1 p, IL-8) and anti-inflammatory (IL-10) cytokines, CRP and tumor necrosis factor (TNF) in moderate and severe preeclampsia in third trimester of pregnancy. Methods: Fifty women with pregnancies complicated by preeclampsia and 50 women with normotensive pregnancy were evaluated in the third trimester of pregnancy. Levels of IL-1β, IL-8, IL-10, and TNF-α were measured by using a solid-phase enzyme immunoassay. Statistical data processing was done using the application program SPSS for Windows 13.0. Descriptive methods (mean, median, min and max) were used in order to describe the distribution of analyzed variables. Results: In severe preeclampsia IL-10 had a downward trend, IL-8 was a relatively stable parameter, and CRP levels tend to be higher in women at the risk of developing preeclampsia. Increasing levels of TNF-α and IL-β between 28-40 weeks of gestation may be considered a prognostic marker for the development of preeclampsia. Conclusion: Analyzing cytokines in third trimester of pregnancy complicated with preeclampsia is useful. Moderate phase can be considered a critical stage in preeclampsia that comes to most functional strain homeostatic system.
- Subjects
CYTOKINES; PREECLAMPSIA; CELLULAR immunity; C-reactive protein
- Publication
Perinatal Journal / Perinatoloji Dergisi, 2015, Vol 23, Issue 3, p186
- ISSN
1300-5251
- Publication type
Article
- DOI
10.2399/prn.15.0233011