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- Title
Effects of perinatal stress on neuroligin-1 and neuroxin Ilα immunreactivity in different structural parts of the rat enteric nervous system.
- Authors
Alim, Ece; Dizakar, Özen Akarca; Gülekon, İsmail Nadir; Ulupmar, Emel; Konaç, Ece; Bahçelioğlu, Meltem
- Abstract
Objective: The relationship between enteric nervous system, gastrointestinal function and stress is very important in clinical and pathophysiological aspects. Neuroligin and neuroxins are synaptic cell adhesion molecules that play a key role in synaptic functions. In recent studies, it is thought that neurologin and neuroxins play an important role in the detection of various cognitive diseases. The bidirectional communication between the brain and the gut, including neuronal, immune and endocrine pathways, is called the brain-gut axis. This axis is affected by various stress factors. In our study, we aimed to investigate the effects of perinatal stress on neuroligin-1 and neuroxin IIa in the enteric nervous system of different intestinal parts of rats at different embryonic / neonatal days. Methods: In our study, 36 female Wistar albino rats were mated. The experimental animals born with the embryos taken at embryonic days E16, E18, E20. of pregnant rats and raised with their mothers until they were weaned (up to postnatal 21st day) were used. There are 8 groups in total in the experiment. Prenatal and/or postnatal stress protocols were applied to the experimental groups. Immunepressions of neuroligin-1 and neuroxin IIa in myenteric plexuses were evaluated of duodenum, jejunum, ileum and colon tissues. Results: When evaluated statistically, the decrease in the percentages of immunoreactivity density and cell positive numbers of neuroligin-1 and neuroxin II- in the myenteric plexuses in the stress groups compared to the control groups is remarkable (p<0.05). Conclusion: Perinatal stress affected the neuroligin-1 and neuroxin IIa immunoreactivities in the enteric nervous system.
- Subjects
ENTERIC nervous system; CELL adhesion molecules; SMALL intestine; EMBRYOS; LABORATORY animals; RATS
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2020, Vol 14, pS101
- ISSN
1307-8798
- Publication type
Article