We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Determination of the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) of selected antimicrobials in bovine and swine Pasteurella multocida, Escherichia coli, and Staphylococcus aureus isolates.
- Authors
Nedbalcová, Kateřina; Nechvátalová, Kateřina; Kučerová, Zdeňka
- Abstract
We compared the values of the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) values of three antimicrobial agents for 72 bovine isolates of Pasteurella multocida, 80 swine isolates of P. multocida, 80 bovine isolates of Escherichia coli, 80 swine isolates of E. coli, and 80 isolates of Staphylococcus aureus from bovine mastitis. The ratio of MIC90/MPC90 which limited mutant selection window (MSW) was ≤ 0.12/4 mg/l for enrofloxacin, 0.5/≥64 mg/l for florfenicol and 4/≥128 mg/l for tulathromycin in bovine P. multocida isolates, ≤ 0.12/2 mg/l for enrofloxacin, 0.5/≥64 mg/l for florfenicol and 4/≥ 128 mg/l for tulathromycin in swine P. multocida isolates, 1/16 mg/l for enrofloxacin, 8/≥64 mg/l for florfenicol and 8/≥128 mg/l for tulathromycin in bovine E. coli isolates, 0.5/16 mg/l for enrofloxacin, ≥64/≥64 mg/l for florfenicol and 8/≥128 mg/l for tulathromycin in swine E. coli isolates, and 0.25/16 mg/l for enrofloxacin, 4/≥64 mg/l for florfenicol and 4/≥128 mg/l for tulathromycin in S. aureus isolates. These findings indicate that the dosage of antimicrobial agents to achieve serum concentration equal to or higher than MPC could reduce selection of resistant bacterial subpopulation.
- Subjects
PASTEURELLA; ANTI-infective agents; PREVENTIVE health services; PREVENTIVE medicine; LIVESTOCK
- Publication
Acta Veterinaria Brno, 2015, Vol 84, Issue 2, p83
- ISSN
0001-7213
- Publication type
Article
- DOI
10.2754/avb201584020083