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- Title
Characteristics and clinical outcomes of adolescents infected by SARS-CoV-2: a systematic review.
- Authors
Gonçalves Campos, Cezenário; Aparecida Muniz, Luciene; Silva Belo, Vinícius; Cristina Costa, Cássia; de Souza Borges Neto, Juscelino; Rachid Novais, Rommel Larcher; Dutra Rabelo, Fernanda Lívia; Martins Júnior, Charles Henrique; Caetano Romano, Márcia Christina; Alves Lamounier, Joel
- Abstract
Objective: To verify the COVID-19 clinical characteristics, associated comorbidities, and outcomes in adolescents. Data source: This is a systematic review study based on articles published between 2020 and 2022 in the United States National Library of Medicine - PubMed (MedLine), Virtual Health Library – VHL (LILACS), Science Direct, Web of Science, and Scopus (Elsevier) databases. The study was registered in the International Prospective Register of Systematic Reviews, under No. CRD42022309108. Data synthesis: A total of 1188 studies were identified. After applying the selection criteria, 13 articles were included. Prevalence was 25%; mild cases were predominant; and fever, cough, headache, anosmia, nasal congestion, and ageusia were frequent. Fever and cough were proportionally higher in hospitalized cases: 81 and 68%, respectively. Dyspnea (odds ratio [OR] 6.3; confidence interval 95%[CI] 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4), and cough (OR 3.4; 95%CI 2.0–6.0) were associated with severe cases. Up to 28% required intensive care and 38% required mechanical ventilation. Pre-existing comorbidities increased the risk of hospitalization and death. Severe cases were associated with the risk of death (relative risk [RR] 4.6; 95%CI 2.8–7.5). The black, mixed, and indigenous races/skin colors represented risk groups, as well as residents of poorer regions. Conclusions: The review provided a better understanding of the disease profile and may favor the development of public policies, in addition to contributing to the current literature in the field of adolescent health.
- Subjects
NATIONAL Library of Medicine (U.S.); SARS-CoV-2; TREATMENT effectiveness; TEENAGERS; DIGITAL libraries; RACE; COUGH
- Publication
Revista Paulista de Pediatria, 2024, Vol 42, p1
- ISSN
0103-0582
- Publication type
Article
- DOI
10.1590/1984-0462/2024/42/2022241