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- Title
Major Hereditary Gastrointestinal Cancer Syndromes: A Narrative Review.
- Authors
Chintalacheruvu, Lakshmi Manogna; Shaw, Trudy; Buddam, Avanija; Diab, Osama; Kassim, Thamer; Mukherjee, Sandeep; Lynch, Henry T.
- Abstract
Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death. In this review, we describe clinical manifestations, genetic testing and its challenges, diagnosis and management of the major hereditary gastrointestinal cancer syndromes.
- Subjects
GASTROINTESTINAL cancer; HEREDITARY cancer syndromes; DIAGNOSTIC ultrasonic imaging; GENETIC testing; CANCER-related mortality; DIAGNOSIS
- Publication
Journal of Gastrointestinal & Liver Diseases, 2017, Vol 26, Issue 2, p157
- ISSN
1841-8724
- Publication type
Article
- DOI
10.15403/jgld.2014.1121.262.maj