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- Title
Lhermitte-Duclos Disease: A Rare Lesion with Variable Presentations and Obscure Histopathology.
- Authors
ÖNDER, Evrim; ARıKÖK, Ata Türker; TÜRKOĞLU, Erhan; ALPER, Murat
- Abstract
Since Lhermitte-Duclos is a quite rare disorder with both neoplastic and hamartomatous features, clinical and pathological diagnosis can sometimes be challenging. For the pathologist it is of extreme importance to be aware of variable clinical and histopathological presentations of such a rare lesion particularly to differentiate it from the low-grade glial and neuronal tumors. We present four cases of Lhermitte-Duclos in a histopathological perspective. Although enlargement of the internal granular layer of the cerebellum is a consistent finding in our cases, morphological severity was highly variable and in some cases the enlargement was insignificant. Frozen sections of one case did not reveal diagnostic findings. The vacuolar change observed in the paraffin sections was obscure in the frozen. Pathological diagnosis of Lhermitte-Duclos disease can be extremely difficult in the absence of proper clinical information and the pathologist should be watchful for any irregularity in the internal granular layer in evaluating the cerebellar tissue which is otherwise normal.
- Subjects
CEREBELLAR tumors; CEREBELLUM diseases; RARE diseases; HISTOPATHOLOGY; HAMARTOMA
- Publication
Turkish Journal of Pathology, 2018, Vol 34, Issue 1, p92
- ISSN
1018-5615
- Publication type
Case Study
- DOI
10.5146/tjpath.2014.01283