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- Title
Copper‐Catalyzed Carbocyclization of Silyl Enol Ether Tethered Ynamides for Efficient and Practical Synthesis of 2‐Azabicyclo[3.2.0] Compounds<sup>†</sup>.
- Authors
Huang, En‐He; Zhang, Zhi‐Xin; Ye, Si‐Han; Chen, Yang‐Bo; Luo, Wen‐Feng; Qian, Peng‐Cheng; Ye, Long‐Wu
- Abstract
Summary of main observation and conclusion: An efficient copper‐catalyzed carbocyclization of silyl enol ether tethered ynamides has been developed, allowing rapid and practical construction of diverse 2‐azabicyclo[3.2.0] compounds in generally good to excellent yields with broad substrate scope under mild reaction conditions. Importantly, this protocol not only constitutes a rare example of non‐noble metal‐catalyzed alkyne carbocyclization, but also represents a rare cyclization on the β‐position of π‐tethered ynamides. The possibility of asymmetric carbocyclization via kinetic resolution also emerges.
- Subjects
SILYL enol ethers; YNAMIDES; KINETIC resolution
- Publication
Chinese Journal of Chemistry, 2020, Vol 38, Issue 10, p1086
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202000218