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- Title
Adult testosterone and calculated free testosterone reference ranges by tandem mass spectrometry.
- Authors
Neale, S. M.; Hocking, R.; Biswas, M.; Turkes, A.; Rees, D.; Rees, D. A.; Evans, C.
- Abstract
Background: Testosterone is measured for the investigation of female hyperandrogenism and male hypogonadism. Liquid chromatography-tandem mass spectrometry (tandem MS) is becoming the method of choice but comprehensive reference ranges are lacking. Methods: Testosterone was measured by tandem MS on 90 healthy women, 67 young healthy men and pregnant women (59 first trimester and 60 second trimester). Results: The male, male calculated free, first trimester and second trimester testosterone reference ranges (derived using the antilog of mean±1.96 SD of log transformed data) were 10.6-31.9, 0.23-0.63, 0.6-4.9 and 0.9-4.9 nmol/L, respectively. The female testosterone upper reference range limit, derived non-parametrically from the 97.5th centile, was <1.7 nmol/L. Conclusions: We have derived tandem MS testosterone reference ranges to support clinical services.
- Subjects
TESTOSTERONE; TANDEM mass spectrometry; HYPERANDROGENISM; HYPOGONADISM; LIQUID chromatography-mass spectrometry
- Publication
Annals of Clinical Biochemistry, 2013, Vol 50, Issue 2, p159
- ISSN
0004-5632
- Publication type
Article
- DOI
10.1258/acb.2012.012047