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- Title
Healing activity of Casearia sylvestris Sw. in second-degree scald burns in rodents.
- Authors
de Campos, Evandro Pedro; Trombini, Letícia Nava; Rodrigues, Rafaela; Portella, Décio Luis; Werner, Adriana Carolina; Ferraz, Miriele Cristina; Machado de Oliveira, Robson Vicente; Cogo, José Carlos; Oshima-Franco, Yoko; Aranha, Norberto; Gerenutti, Marli
- Abstract
Background: Every year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Caseariasyl-vestris Sw., popularly known as guacatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries. Methods: The obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothropsjararacussu snake venom that is necrotic and inflammatory, and by which guacatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract. Results: Significant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization. Conclusion: The anti-inflammatory and bactericidal effects of C sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B.jararacussu venom.
- Subjects
MEDICAL care; BIOFILMS; CHROMATOGRAPHIC analysis; ANTI-inflammatory agents; NEOVASCULARIZATION
- Publication
BMC Research Notes, 2015, Vol 8, Issue 1, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-015-1251-4