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- Title
PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers.
- Abstract
The article offers information on the study conducted by the authors related to PTPN22 polymorphisms that may indicate a role for this gene in atopic dermatitis in West Highland white terriers. It states that canine atopic dermatitis is an allergic inflammatory skin disease common in West Highland white terriers. A genome-wide association study for atopic dermatitis in a population of West Highland white terriers identified an area of association on CFA17 containing canine protein tyrosine phosphatase non-receptor type 22 (lymphoid) PTPN22. This gene is a potential candidate gene for canine atopic dermatitis as it encodes a lymphoid-specific signaling mediator that regulates T-cell and possibly B-cell activity.
- Publication
BMC Research Notes, 2011, Vol 4, Issue 1, p571
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/1756-0500-4-571