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- Title
Isothiochromenothiazoles--A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei.
- Authors
Kryshchyshyn, Anna; Kaminskyy, Danylo; Nektegayev, Igor; Grellier, Philippe; Lesyk, Roman
- Abstract
Recently, thiazolidinone derivatives have been widely studied as antiparasitic agents. Previous investigations showed that fused 4-thiazolidinone derivatives (especially thiopyranothiazoles) retain pharmacological activity of their synthetic precursors--simple 5-ene-4-thiazolidinones. A series of isothiochromeno[4a,4-d][1,3] thiazoles was investigated in an in vitro assay towards bloodstream forms of Trypanosoma brucei brucei. All compounds inhibited parasite growth at concentrations in the micromolar range. The established low acute toxicity of this class of compounds along with a good trypanocidal profile indicates that isothiochromenothiazole derivatives may be promising for designing new antitrypanosomal drugs.
- Subjects
THIAZOLIDINEDIONES; ANTINEOPLASTIC agents; TRYPANOSOMA brucei; ACUTE toxicity testing; PHARMACOLOGY
- Publication
Scientia Pharmaceutica, 2018, Vol 86, Issue 4, p1
- ISSN
0036-8709
- Publication type
Article
- DOI
10.3390/scipharm86040047