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- Title
Detection of glutathione based on MnO<sub>2</sub> nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter.
- Authors
Qingqing Tan; Ruirui Zhang; Rongmei Kong; Weisu Kong; Wenzhi Zhao; Fengli Qu
- Abstract
The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO2 nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO2 nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 µM concentration range, with a 34 nM limit of detection.
- Subjects
SILICA nanoparticles; GLUTATHIONE; GLUCOSE; NANOSTRUCTURED materials; ELECTROSTATIC interaction; MESOPOROUS silica
- Publication
Microchimica Acta, 2018, Vol 185, Issue 1, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-017-2603-7