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- Title
Transvaginal perfusion of granulocyte colony stimulating factor for infertile women with thin endometrium in frozen ET program: A nonrandomized clinical trial.
- Authors
Arabjahvani F.; Eftekhar M.; Sayadi M.
- Abstract
Introduction: We often see patients with a thin endometrium in ART cycles, in spite of standard and adjuvant treatments. Improving endometrial growth in patients with a thin endometrium is very difficult. Without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. We planned this study to investigate the efficacy of intrauterine granulocyte colony stimulating factor (GCSF) perfusion in improving endometrium, and possibly pregnancy rates in frozen-thawed embryo transfer cycles. Materials and Methods: This is a non-randomized intervention clinical trial. Among 68 infertile patients with thin endometrium (-7 mm) at the 12th-13th cycle day, 34 patients received GCSF (300 microgram/lmL) to improve endometrial thickness by direct administration by slow intrauterine infusion using IUI catheter. If the endometrium had not reached at least to 7-mm within 48-72 hr, a second infusion was given. Endometrial thickness was assessed by serial vaginal ultrasound at the most expanded area of the endometrial stripe. Results: The cycle was cancelled in the patients with thin endometrium (endometrial thickness below 7mm) until 19th cycle day ultimately. The cycle cancelation rate owing to thin endometrium was similar in GCSF group (15.20%), followed by (15.20%) in the control group (p=1.00). The endometrial growth was not different within 2 groups, an improvement was shown between controlled and GCSF co-treated groups, with chemical (39.30% vs. 14.30%) and clinical pregnancy rates (32.10% vs. 12.00%) although the differences were not significant. Conclusion: Our study fails to demonstrate that GCSF has the potential to improve endometrial thickness but it shows that GCSF has the potential to improve chemical and clinical pregnancy rate of the infertile women with thin endometrium in frozen-thawed embryo transfer cycle.
- Subjects
FEMALE infertility; REPRODUCTIVE technology
- Publication
Iranian Journal of Reproductive Medicine, 2015, p16
- ISSN
1680-6433
- Publication type
Abstract