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- Title
Serum Troponin I Level for Diagnosis of Acute Coronary Syndrome in Patients with Chronic Kidney Disease.
- Authors
Jafari Fesharaki, Mehrdad; Alipour Parsa, Saeed; Nafar, Mohsen; Ghaffari-Rahbar, Maryam; Omidi, Fatemeh; Karimi-Sari, Hamidreza
- Abstract
<bold>Introduction: </bold>Myocardial infarction is a common cause of mortality in patients with chronic kidney disease (CKD). Since troponins I and T levels rise in CKD patients without any myocardial cause, diagnostic value of cardiac troponins is not high in these patients. This study aimed to evaluate the value of troponin I and other cardiac biomarkers to differentiate acute coronary syndrome in CKD patients.<bold>Materials and Methods: </bold>In this cross-sectional study, patients with stage 3 to 5 of CKD with typical chest pain were enrolled. Troponins I and T and other biomarkers were measured, and angiography was carried out in these patients. Cardiac biomarkers and other variables were evaluated in patients and compared with angiography results.<bold>Results: </bold>Ninety CKD patients with a mean age of 61.67 ± 15.87 years were enrolled. Angiography results were normal in 48.9% of the patients, while it showed single-vessel disease in 14.5%, two-vessel disease in 23.3%, and three-vessel disease in 13.3%. Serum creatinine level, glomerular filtration rate, troponin I level, and creatine kinase level were not significantly different in patients with normal and abnormal angiography findings. The serum troponin I, creatine kinase, and creatine kinase-myocardial bound levels had no significant diagnostic values to differentiate abnormal angiography in CKD patients.<bold>Conclusions: </bold>Serum levels of cardiac troponin I and creatine kinase-myocardial bound were not suitable to diagnose ACS in CKD patients (stages 3 to 5); therefore, we suggest using other diagnostic attempts in similar conditions. More evaluation is needed to confirm these findings.
- Subjects
CHRONIC kidney failure complications; ANGIOGRAPHY; CHEST pain; CHRONIC kidney failure; CREATINE kinase; CREATININE; GLOMERULAR filtration rate; CROSS-sectional method; RECEIVER operating characteristic curves; ACUTE coronary syndrome; TROPONIN; DISEASE complications; DIAGNOSIS
- Publication
Iranian Journal of Kidney Diseases, 2016, Vol 10, Issue 1, p11
- ISSN
1735-8582
- Publication type
journal article