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- Title
Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance.
- Authors
Lacombe, Séverine; Rougon-Cardoso, Alejandra; Sherwood, Emma; Peeters, Nemo; Dahlbeck, Douglas; Van Esse, H. Peter; Smoker, Matthew; Rallapalli, Ghanasyam; Thomma, Bart P. H. J.; Staskawicz, Brian; Jones, Jonathan D. G.; Zipfel, Cyril
- Abstract
Plant diseases cause massive losses in agriculture. Increasing the natural defenses of plants may reduce the impact of phytopathogens on agricultural productivity. Pattern-recognition receptors (PRRs) detect microbes by recognizing conserved pathogen-associated molecular patterns (PAMPs). Although the overall importance of PAMP-triggered immunity for plant defense is established, it has not been used to confer disease resistance in crops. We report that activity of a PRR is retained after its transfer between two plant families. Expression of EFR (ref. 4), a PRR from the cruciferous plant Arabidopsis thaliana, confers responsiveness to bacterial elongation factor Tu in the solanaceous plants Nicotiana benthamiana and tomato (Solanum lycopersicum), making them more resistant to a range of phytopathogenic bacteria from different genera. Our results in controlled laboratory conditions suggest that heterologous expression of PAMP recognition systems could be used to engineer broad-spectrum disease resistance to important bacterial pathogens, potentially enabling more durable and sustainable resistance in the field.
- Subjects
PLANT diseases; PLANT defenses; PLANT immunology; PATTERN perception; DISEASE resistance of plants; PLANT genetics
- Publication
Nature Biotechnology, 2010, Vol 28, Issue 4, p365
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.1613