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- Title
Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation.
- Authors
Song, Myoung-Chong; Yang, Hye-Joung; Jeong, Tae-Sook; Kim, Kyong-Tai; Baek, Nam-In
- Abstract
The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and H2O, successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5′-dibuthoxy-2,2′-bifuran ( 1) along with five known compounds: methyl trans-ferulate ( 2), prunasin ( 3), sambunigrin ( 4), pterolactam ( 5), and adenosine ( 6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The IC50 values of compound 1 for human Acyl-CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an IC50 value of 7.7 μM.
- Publication
Archives of Pharmacal Research, 2008, Vol 31, Issue 5, p573
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-001-1195-4