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- Title
cytotoxic germacranolide sesquiterpene lactones from Carpesium triste var. manshuricum.
- Authors
Kim, Mi-; Hwang, Bang; Jeong, Eun-Sook; Lee, Yong-Moon; Yoo, Hwan-Soo; Chung, Youn-; Hong, Jin; Moon, Dong-Cheul
- Abstract
Four known germacranolide sesquiterpene lactones, 2α,5-epoxy-5,10-dihydroxy-6α-angeloy-loxy-9β-isobutyloxy-germacran-8α,12-olide (1), 2α,5-epoxy-5,10-dihydroxy-6α, 9β-diangeloy-loxy-germacran-8α,12-olide (2, divaricin B), 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(2-methylbutyloxy)-germacran-8α,12-olide (3) and 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methylbutyloxy)-germacran-8α,12-olide (4), were isolated from the chloroform-soluble fraction of the whole plants of Carpesium triste var. manshuricum. Their chemical structures were determined using spectroscopic methods, including 2D-NMR. All the isolates showed significant cytotoxicities (ED50 value: 4.3–16.8 μM) against five human tumor cell lines; A549, SK-OV-3, SK-MEL-2, XF498 and HCT15.
- Publication
Archives of Pharmacal Research, 2007, Vol 30, Issue 5, p556
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02977648