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- Title
The protective effects of phenolic constituents from Gastrodia elata on the cytotoxicity induced by KCl and glutamate.
- Authors
Huang, Zhan-Bo; Wu, Zhe; Chen, Fa-Kui; Zou, Li-Bo
- Abstract
Seven phenolic compounds ( 1–7) were isolated from the tubers of Gastrodia elata. Their structures were elucidated on the basis of MS and NMR spectral data. p-Ethoxymethyl phenyl- O-β- D-glucoside ( 1) was proved to be a new compound, with N-( p-hydroxybenzyl)-adenosine ( 7) isolated from this plant for the first time. In this study, the protective effects of the six constituents ( 1–6) on PC12 cells against the cytotoxicity induced by KCl and glutamate were also investigated. The viability of the PC12 cells was significantly enhanced by pretreatment with the six phenolic constituents.
- Publication
Archives of Pharmacal Research, 2006, Vol 29, Issue 11, p963
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02969279