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- Title
SPan-1 Is a Useful Prognostic Marker for Patients with Stage IV Gastric Cancer Who Underwent Palliative Gastrectomy: A Retrospective Multivariate Study.
- Authors
Kubo, Naoshi; Ohira, Masaichi; Sakurai, Katsunobu; Toyokawa, Takahiro; Tanaka, Hiroaki; Muguruma, Kazuya; Nagahara, Hisashi; Kimura, Kenjiro; Noda, Eiji; Amano, Ryosuke; Yamada, Nobuya; Yashiro, Masakazu; Maeda, Kiyoshi; Sawada, Tetsuji; Hirakawa, Kosei
- Abstract
Background: We retrospectively investigated prognostic factors to be used in selecting the patients with stage IV gastric cancer (GC) who have an unfavorable prognosis after palliative gastrectomy. Methods: A total of 146 GC patients at stage IV who had undergone palliative gastrectomy were enrolled. Various clinicopathological parameters were evaluated for prognosis. Results: Surgical morbidity and hospital mortality occurred in 35 (23.9 %) and 4 (2.7 %) patients, respectively. The overall 5-year survival rate and the median survival time were 11.2 % and 13.2 months, respectively. Of the 146 patients, 64 had uncomfortable symptoms associated with GC and 76 had no such symptoms. Of the 64 patients with uncomfortable symptoms, 60 (93.7 %) experienced relief of these symptoms after palliative surgery. Multivariate analysis for patients without uncomfortable symptoms associated with GC revealed that the number of incurable factors and serum SPan-1 level were independent prognostic factors. Conclusions: Patients with stage IV GC who had multiple incurable factors and a high level of serum SPan-1 might not be candidates for palliative gastrectomy for the purpose of prognostic benefit.
- Subjects
STOMACH cancer patients; GASTRECTOMY; PALLIATIVE treatment; MULTIVARIATE analysis; STOMACH surgery; SERUM
- Publication
World Journal of Surgery, 2013, Vol 37, Issue 7, p1681
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-013-2016-7