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- Title
Half-life Estimation of Pertussis-Specific Maternal Antibodies in (Pre)Term Infants After In-Pregnancy Tetanus, Diphtheria, Acellular Pertussis Vaccination.
- Authors
Embacher, Stefan; Maertens, Kirsten; Herzog, Sereina A
- Abstract
Background To reduce the risk of pertussis-related morbidity and mortality in early life, an increasing number of countries recommend maternal pertussis vaccination. However, there is limited knowledge about half-lives of vaccine-induced pertussis-specific maternal antibodies, especially in preterm infants, and factors potentially influencing them. Methods We compared 2 different approaches to provide estimates of the half-lives of pertussis-specific maternal antibodies in infants and explored potential effects on the half-life in 2 studies. In the first approach, we estimated the half-lives per child and used these estimates as responses in linear models. In the second approach, we used linear mixed effect models on a log2 transformed scale of the longitudinal data to use the inverse of the time parameter as an estimate for the half-lives. Results Both approaches provided similar results. The identified covariates partly explain differences in half-life estimates. The strongest evidence we observed was a difference between term and preterm infants, with the preterm infants showing a longer half-life. Among others, a longer interval between vaccination and delivery increases the half-life. Conclusions Several variables influence the decay speed of maternal antibodies. Both approaches have advantages and disadvantages, while the choice is secondary when assessing the half-life of pertussis-specific antibodies. Clinical Trials Registration NCT02408926 and NCT02511327.
- Subjects
WHOOPING cough vaccines; CLINICAL trial registries; DIPHTHERIA; PREMATURE infants; TETANUS
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 11, p1640
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad212