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- Title
HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia.
- Authors
Sun Zi-Min; Liu Hui-Lan; Geng Liang-Quan; Wang Xin-Bing; Yao Wen; Liu Xin; Ding Kai-Yang; Han Yong-Sheng; Yang Hui-Zhi; Tang Bo-lin; Tong Juan; Zhu Wei-Bov; Wang Zu-Yi
- Abstract
Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the early morbidity in Allo-HSCT. Methods: To reduce graft failure and GVHD, we treated fifteen patients with SAA using high- dose of HSCT with both G-CSF mobilized PB and BMSCs from HLA-identical siblings to treat patients with SAA. Results: All patients had successful bone marrow engraftment. Only one patient had late rejection. Median time to ANC greater than 0.5 × 109/L and platelet counts greater than 20 × 109/L was 12 and 16.5 days, respectively. No acute GVHD was observed. The incidence of chronic GVHD was 6.67%. The total three-year probability of diseasefree survival was 79.8%. Conclusion: HSCT with both G-CSF mobilized PB and BMSCs is a promising approach for heavily transfused and/or allo-immunized patients with SAA.
- Subjects
STEM cells; CELL transplantation; HEMATOPOIESIS; APLASTIC anemia treatment; GRAFT versus host disease; PATIENTS; BONE marrow; MEDIAN (Mathematics); ERYTHROPOIESIS
- Publication
Journal of Hematology & Oncology, 2010, Vol 3, p51
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/1756-8722-3-51