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- Title
Current status of platelet manufacturing in 3D or bioreactors.
- Authors
Kweon, Soonho; Kim, Suyeon; Choi, Hye Sook; Jo, Kyeongwon; Park, Ju Mi; Baek, Eun Jung
- Abstract
Blood shortages for transfusion are global issues of grave concern. As in vitro manufactured platelets are promising substitutes for blood donation, recent research has shown progresses including different cell sources, different bioreactors, and three‐dimensional materials. The first‐in‐human clinical trial of cultured platelets using induced pluripotent stem cell‐derived platelets began in Japan and demonstrated its quality, safety, and efficacy. A novel bioreactor with fluid motion for platelet production has been reported. Herein, we discuss various cell sources for blood cell production, recent advances in manufacturing processes, and clinical applications of cultured blood.
- Subjects
JAPAN; BIOREACTORS; BLOOD cells; BLOOD substitutes; MANUFACTURING processes; BLOOD transfusion
- Publication
Biotechnology Progress, 2023, Vol 39, Issue 5, p1
- ISSN
8756-7938
- Publication type
Article
- DOI
10.1002/btpr.3364