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- Title
Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT[sub4] Receptor Knock-Out Mice.
- Authors
Compan, Valérie; Mingming Zhou; Grailhe, Régis; Gazzara, Russell A.; Martin, Renee; Gingrich, Jay; Dumuis, Aline; Brunner, Daniela; Bockaert, Joël; Hen, René
- Abstract
To study the functions of 5-HT[sub4] receptors, a null mutation was engineered in the corresponding gene. 5-HT[sub4] receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response, to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT[sub4] receptors may be involved in stress-induced anorexia and seizure susceptibility.
- Subjects
NEURAL receptors; APPETITE loss; PHYSIOLOGICAL stress; PSYCHOLOGICAL stress; MICE; MOTOR ability
- Publication
Journal of Neuroscience, 2004, Vol 24, Issue 2, p412
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2806-03.2004