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- Title
The maximum standardized uptake value of <sup>18</sup> F-FDG PET scan to determine prognosis of hormone-receptor positive metastatic breast cancer.
- Authors
Jian Zhang; Zhen Jia; Joseph Ragaz; Ying-Jian Zhang; Min Zhou; Yong-Ping Zhang; Gang Li; Bi-Yun Wang; Zhong-Hua Wang; Xi-Chun Hu
- Abstract
Background: Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated. Methods: 305 MBC patients with luminal subtypes were screened with PET/CT. Eligible patients were prospectively followed up. Results: In total, 134 patients were eligible for this study. SUVmax was significantly related to the number of metastatic sites and presence of visceral metastasis on univariate analysis. SUVmax could not effectively differentiate patients with luminal A from luminal B subtype. Although luminal subtype at diagnosis could predict the relapse-free interval, it could not predict progression-free survival (PFS) or overall survival (OS) after developing relapse. In contrast, SUVmax was predictive of both PFS and OS and this effect was maintained in multivariate COX regression model. Conclusions: SUVmax of MBC did not correlate with molecular subtypes of primary tumor. While molecular subtype may be a valuable prognostic factor at primary diagnosis of breast cancer, the SUVmax, rather than molecular subtype, does have a potential to predict independently in multivariate analysis for the PFS and OS in patients with metastatic disease of luminal subtype.
- Subjects
POSITRON emission tomography; HORMONE receptors; BREAST cancer prognosis; METASTASIS; UNIVARIATE analysis; REGRESSION analysis
- Publication
BMC Cancer, 2013, Vol 13, Issue 1, p1
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/1471-2407-13-42