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- Title
The effect of 12 weeks of aerobic exercise on mitochondrial dynamics in cardiac myocytes of type 2 diabetic rats.
- Authors
Zafaranieh, Saghi; Choobineh, Siroos; Soori, Rahman
- Abstract
Background: Mitochondrial dynamics disorders contribute to the pathogenesis of many diseases involving type 2 diabetes. It appears that exercise training is a strategy for reversing the unbalance between fusion and fission, but, to our understanding, effects of aerobic exercise on this particular issue have not been studied in cardiac myocytes.Aims: To demonstrate if 12 weeks of aerobic exercise has a significant impact on Dynamin Related Protein 1 (DRP1), Mitofusin2 (MFN2) and Optic Atrophy 1 (OPA1) expressions in cardiac muscle of type 2 diabetic rats.Methods: 10 Wistar rats with an average age of 10 weeks were divided randomly into two groups of five: diabetic control and diabetic exercise. The latter was submitted to a 12-week (5 days a week, 30 min/day) aerobic exercise. 48 h after the last session of exercise, cardiac samples were obtained for genetic experiments. T-test was used for data analysis at p ≤ 0.05.Results: OPA1 expression was increased significantly (p = 0.03) while MFN2 and DRP1 expressions were elevated insignificantly (p = 0.165, p = 0.19).Conclusion: This study shows that aerobic training is likely to regulate mitochondrial fission and fusion in cardiac muscle of type 2 diabetic rats. Although more research is necessary.
- Subjects
AEROBIC exercises; MUSCLE cells; PEOPLE with diabetes; LABORATORY rats; TYPE 2 diabetes; PHYSIOLOGY
- Publication
Sport Sciences for Health, 2018, Vol 14, Issue 2, p305
- ISSN
1824-7490
- Publication type
Article
- DOI
10.1007/s11332-018-0430-9