The article discusses the next-generation sequencer market led by Illumina. The Insight Pharma Report shows that Roche/454 and Applied Biosystems/SOLiD are in a second tier. Helicos, whose product is HeliScope, entered the market in 2008 with its first single-molecule sequencer, capturing the fourth position. According to the article, many smaller companies have technologies that are more advantageous than the other systems.