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- Title
Chemical composition analysis of Angelica sinensis (Oliv.) Diels and its four processed products by ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry combining with nontargeted metabolomics.
- Authors
Wang, Kangyu; Liu, Xiaokang; Cai, Guangzhi; Gong, Jiyu; Guo, Yunlong; Gao, Wenyi
- Abstract
Angelica sinensis (Oliv.) Diels. has been used for women to enrich the blood, prevent and treat blood deficiency syndrome in Traditional Chinese Medicine for thousands of years. Wine‐processed Angelica sinensis, soil‐processed Angelica sinensis, oil‐processed Angelica sinensis, and charred‐processed Angelica sinensis are the most significant four processed products used in Chinese clinic. However, there have been few studies aimed at comparing their chemical differences. Ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry combining with nontargeted metabolomics was applied to investigate the diversity of processed products of Angelica sinensis. A total of 74 compounds with the variable importance in the projection value more than 1.5 and P less than 0.05 in ANOVA were highlighted as the compounds that contribute most to the discrimination of Angelica sinensis and four processed products. The results showed the metabolic changes between Angelica sinensis and its four processed products, there were 19 metabolites, 3 metabolites, 6 metabolites, and 45 metabolites were tentatively assigned in soil‐processed Angelica sinensis, wine‐processed Angelica sinensis, oil‐processed Angelica sinensis, and charred‐processed Angelica sinensis, respectively. These results suggested that the proposed metabolomics approach was useful for the quality evaluation and control of processed products of Angelica sinensis.
- Subjects
DONG quai; QUADRUPOLE ion trap mass spectrometry; LIQUID chromatography; MASS spectrometry; ANALYTICAL chemistry; METABOLOMICS
- Publication
Journal of Separation Science, 2023, Vol 46, Issue 24, p1
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.202300473