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- Title
Amperometric Sarcosine Biosensors Based on Electrodeposited Conductive Films Contain Indole-6-carboxylic Acid.
- Authors
Xiaofang Zhang; Jing Chen; Qia Wang; Bing Du; Gaochao Fan; Weidong Zheng; Haipeng Yang; Tailin Xu
- Abstract
Sarcosine level in serum is of important clinical significance in distinguishing prostate cancer. This work depicts an amperometric sarcosine biosensor with good anti-interference performance by electro-codepositing manganese phosphate, 3,4-ethylenedioxythiophene (EDOT) and indole-6-carboxylic acid (IA) on the glass carbon electrode. The prepared sarcosine biosensor has a wide linear detection range (1-55 µM) with a low detection limit of 0.11 µM. This work provides an antiinterference approach by controlling the surface charge density of the biosensor to sarcosine sensing, which has great potential to be used as point of care testing (POCT) device for the rapid detection of prostate cancer biomarkers.
- Subjects
POINT-of-care testing; TUMOR markers; SURFACE charges; CARBON electrodes; BIOSENSORS; PROSTATE cancer
- Publication
Electroanalysis, 2022, Vol 34, Issue 2, p345
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.202100225