We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cell adhesion molecule L1 affects the rate of differentiation of enteric neurons in the developing gut.
- Authors
Turner, Kirsty N.; Schachner, Melitta; Anderson, Richard B.
- Abstract
The enteric nervous system arises predominantly from vagal level neural crest cells that migrate into and along the developing gut. As the neural crest-derived cells migrate within the gut, a subpopulation begins to differentiate into enteric neurons. Here, we show that the differentiation of neural crest-derived cells into enteric neurons is delayed in L1-deficient mice, compared with littermate controls. However, glial cell differentiation is not affected in L1-deficient mice. These mice also show a delay in the differentiation of a neurotransmitter-specific subtype of enteric neuron within the gastrointestinal tract. Together, these results suggest a role for the cell adhesion molecule, L1, in the differentiation of neural crest-derived cells into enteric neurons within the developing enteric nervous system. Developmental Dynamics 238:708-715, 2009. © 2009 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2009, Vol 238, Issue 3, p708
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.21861