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- Title
Facile radiosynthesis of F-labeled β-glutamic acid as a new PET tracer for imaging lung cancer.
- Authors
Liu, Shaoyu; Sun, Aixia; Zhang, Zhanwen; Nie, Dahong; Tang, Xiaolan; Ma, Hui; Jiang, Shende; Tang, Ganghua
- Abstract
In this paper, N-(2-[F]fluoropropionyl)-β-glutamic acid 8 ([F]FP-β-Glu), a new N-substituted F-labeled amino acid tracer, was synthesized from the precursor 4 (diethyl 3-(2-bromopropanamido)pentanedioate) via a two-step reaction on the modified FDG synthesizer. The radiochemical yield was 20 ± 5% ( n = 10, decay-corrected) from [F]fluoride within 40 min, the radiochemical purity was 98%. Moreover, microPET studies showed that [F]FP-β-Glu 8 exhibited rapid tumor uptake and good tumor-to-lung ratio in SPC-A-1 tumor-bearing mice. A high accumulation of radioactivity was found in the kidneys and bladder, which suggested that the tracer was mainly eliminated through the urinary system.
- Subjects
RADIOACTIVE tracers; GLUTAMIC acid; POSITRON emission tomography; RADIOACTIVITY; RADIOCHEMICAL purification
- Publication
Journal of Radioanalytical & Nuclear Chemistry, 2017, Vol 312, Issue 2, p233
- ISSN
0236-5731
- Publication type
Article
- DOI
10.1007/s10967-017-5220-3