We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dual delivery of hydrophilic and hydrophobic drugs from chitosan/diatomaceous earth composite membranes.
- Authors
López-Cebral, Rita; Peng, Guangjia; Reys, Lara L.; Silva, Simone S.; Oliveira, Joaquim M.; Chen, Jie; Silva, Tiago H.; Reis, Rui L.
- Abstract
Oral administration of drugs presents important limitations, which are frequently not granted the importance that they really have. For instance, hepatic metabolism means an important drug loss, while some patients have their ability to swell highly compromised (i.e. unconsciousness, cancer…). Sublingual placement of an accurate Pharmaceutical Dosage Form is an attractive alternative. This work explores the use of the β-chitosan membranes, from marine industry residues, composed with marine sediments for dual sublingual drug delivery. As proof of concept, the membranes were loaded with a hydrophilic (gentamicin) and a hydrophobic (dexamethasone) drug. The physico-chemical and morphological characterization indicated the successful incorporated of diatomaceous earth within the chitosan membranes. Drug delivery studies showed the potential of all formulations for the immediate release of hydrophilic drugs, while diatomaceous earth improved the loading and release of the hydrophobic drug. These results highlight the interest of the herein developed membranes for dual drug delivery.<graphic></graphic>
- Subjects
HYDROPHILIC compounds; HYDROPHOBIC compounds; CHITOSAN; COMPOSITE membranes (Chemistry); DOSAGE forms of drugs
- Publication
Journal of Materials Science: Materials in Medicine, 2018, Vol 29, Issue 2, p0
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-018-6025-9